منابع مشابه
Robustness, evolvability, and neutrality.
Biological systems, from macromolecules to whole organisms, are robust if they continue to function, survive, or reproduce when faced with mutations, environmental change, and internal noise. I focus here on biological systems that are robust to mutations and ask whether such systems are more or less evolvable, in the sense that they can acquire novel properties. The more robust a system is, th...
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2190 O ne of the most important features of biology is the ability of organisms to persist in the face of changing conditions. Consider the remarkable fact that every organism alive today is the product of billions of generations in which its progenitors, without fail, managed to produce progeny that survived to reproduce. To achieve this consistency, organisms must have a balance between robus...
متن کاملRobustness of Evolvability
A framework for analyzing the computational capabilities and the limitations of the evolutionary process of random change guided by selection was recently introduced by Valiant [Val06]. In his framework the process of acquiring a complex functionality is viewed as a constrained form of PAC learning. In addition to the basic definition, a number of natural variants of the evolvability model were...
متن کاملNear-Neutrality, Robustness, and Epigenetics
The nearly neutral theory emphasizes the interaction of drift and weak selection in evolution. With progress of genome biology, the applicability of the nearly neutral theory has expanded. The genome-wide analyses of synonymous and nonsynonymous substitutions at protein-coding regions show prevalence of very weak selection. Many patterns of evolution of gene regulation are also in agreement wit...
متن کاملRobustness and evolvability in genetic regulatory networks.
Living organisms are robust to a great variety of genetic changes. Gene regulation networks and metabolic pathways self-organize and reaccommodate to make the organism perform with stability and reliability under many point mutations, gene duplications and gene deletions. At the same time, living organisms are evolvable, which means that these kind of genetic perturbations can eventually make t...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2005
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2005.01.063